Dopamine D2 receptor risk_factor_for schizophrenia

Four genes (DRD2, GRM3, NOTCH4, and TNF) are genome-wide significant in the PGC analysis

DRD2 ... have genome-wide significant evidence for common variant association with schizophrenia

DRD2 was rated as highly likely to be a genetic risk factor for schizophrenia (rating ≥4 on a 1–5 scale) and is the exception supported by SZGene or PGC mega-analysis.