GABRA2 risk_factor_for ethanol dependence

Subject: GABRA2
Relation: risk_factor_for
Object: ethanol dependence
p-value: —

Evidence from: primary | all sources

Evidence (2 sources)

Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration. (2012) PMID:23115637 cited

potential role for the GABAA α2-subunit ... may contribute to the development of dependence to ethanol

confidence: 0.92

The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. (2009) PMID:19455309 cited

COGA found increased allele sharing among ethanol-dependent individuals in a region that includes GABRA2.

confidence: 0.95