β-endorphin interacts_with OPRM1
Evidence from:
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Evidence (4 sources)
MOR is activated by both endomorphins and β-endorphin, a cleavage product of the proopiomelanocortin precursor.
confidence: 0.96
β-endorphin has higher binding affinity and increased signaling at the variant receptor.
confidence: 0.85
Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects.
(2013)
PMID:23402298
cited
The peptide interacts primarily with the μ-opioid peptide (MOP) receptor
confidence: 0.97
A genetic determinant of the striatal dopamine response to alcohol in men.
(2011)
PMID:20479755
cited
nonradioactive β-endorphin ... ranging from 0.01nM to 1000 nM ... assessed for membrane binding
confidence: 0.85