depression risk_factor_for substance use

identifying individuals with depression at high genetic risk for developing SUD ... possibly preventing the subsequent development of SUD

higher risk of developing SUD among depression cases in the 10th decile compared to the middle deciles

Individuals diagnosed with depression have an increased risk of developing ... substance use disorder (SUD).

Individuals diagnosed with depression are at an increased risk of developing other psychiatric disorders...

depression ... were associated with a greater number of substance dependence diagnoses

others may increase it (e.g., depression in adolescence)

symptoms of depression ... predict substance involvement into late-adolescence

effect of depression on SUDs is larger than previously found in the population at large