Kcnj6 regulates short-term potentiation

Subject: Kcnj6
Relation: regulates
Object: short-term potentiation
p-value: 0.021

Evidence from: primary | all sources

Evidence (2 sources)

Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome. (2017) PMID:28342823 cited

Increased Kcnj6 dose was therefore necessary for deficits in STP ... both STP and LTP were greater in Ts65Dn:Kcnj6++− vs. Ts65Dn:Kcnj6+++ mice (p = 0.021 for STP)

confidence: 0.93

Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome. (2017) PMID:28342823 cited

Reduction of the Kcnj6 gene dose restored ... short- and long-term potentiation in the DG.

confidence: 0.94