polygenic risk score risk_factor_for bipolar disorder
Evidence from:
primary |
all sources
Evidence (4 sources)
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.
(2023)
PMID:37464041
cited
HRR increased with higher polygenic loads and was statistically significant for the 10th PRS decile... absolute risk for bipolar disorder reaching 13% in the 10th decile.
confidence: 0.94
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.
(2023)
PMID:37464041
cited
Highest PRS deciles were associated with increased risk of developing bipolar disorder.
confidence: 0.94
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.
(2021)
PMID:34002096
cited
individuals in the top 10% of BD PRS had an odds ratio of 3.5 ... of being affected with the disorder compared with individuals in the middle decile
confidence: 0.96
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.
(2021)
PMID:34002096
cited
individuals in the top 10% of PRS had an OR of 3.5 for BD
confidence: 0.97