GABRA2 risk_factor_for alcohol dependence

Subject: GABRA2
Relation: risk_factor_for
Object: alcohol dependence
p-value: —

Evidence from: primary | all sources

Evidence (14 sources)

Large-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity. (2021) PMID:34291596 primary

Alcohol dependence has been found to be linked to SNPs in ... GABRA2.

confidence: 0.96

Candidate gene-environment interaction research: reflections and recommendations. (2015) PMID:25620996 primary

Association between GABRA2 and alcohol dependence was subsequently reported

confidence: 0.94

Common biological networks underlie genetic risk for alcoholism in African- and European-American populations. (2013) PMID:23607416 primary

including the often replicated GABRA2 ... have been implicated in alcoholism susceptibility

confidence: 0.95

Gene-environment interaction in psychological traits and disorders. (2011) PMID:21219196 primary

risk related to genes associated with alcohol dependence ... GABRA2

confidence: 0.92

Co-occurring risk factors for alcohol dependence and habitual smoking: update on findings from the Collaborative Study on the Genetics of Alcoholism. (2006) PMID:17373405 primary

several association studies have implicated GABRA2 in alcohol dependence

confidence: 0.95

Co-occurring risk factors for alcohol dependence and habitual smoking: update on findings from the Collaborative Study on the Genetics of Alcoholism. (2006) PMID:17373405 primary

variations in GABA receptors are involved in both alcohol dependence ... differences in the GABRA2 gene ...

confidence: 0.95

GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures. (2015) PMID:26250693 cited

GABRA2 polymorphisms influence risk for AD

confidence: 0.93

Genome-wide association discoveries of alcohol dependence. (2014) PMID:25278008 cited

GABAergic genes (e.g., GABRA2 ...) are risk genes for alcohol dependence

confidence: 0.95

Heritability and molecular-genetic basis of resting EEG activity: a genome-wide association study. (2014) PMID:25387704 cited

associations between the GABRA2 gene and ... alcohol ... dependence

confidence: 0.85

Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. (2012) PMID:21483437 cited

association with alcohol dependence may not emerge until the mid‑20’s

confidence: 0.90

The genetics of alcohol dependence: advancing towards systems-based approaches. (2012) PMID:22854292 cited

variation within an AD susceptibility gene (GABRA2; rs279871) ... AD susceptibility gene.

confidence: 0.90

An Interdisciplinary Approach to Studying Gene-Environment Interactions: From Twin Studies to Gene Identification and Back. (2011) PMID:34385894 cited

Alcohol-dependent individuals were more likely to carry a particular version of the GABRA2 receptor gene, suggesting involvement in predisposition to alcohol dependence.

confidence: 0.97

Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes? (2009) PMID:19183129 cited

variation in these regions does affect ... dependence risk ... particularly on the ADH1B and GABRA2 genes

confidence: 0.95

Genetic and environmental influences on externalizing behavior and alcohol problems in adolescence: a female twin study. (2009) PMID:19341765 cited

consistent elevation in risk for alcohol dependence that is associated with GABRA2

confidence: 0.95