rare CNVs risk_factor_for schizophrenia
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Evidence (8 sources)
Multiple rare CNVs have been implicated; ... all increase risk for several psychiatric disorders ...
confidence: 0.93
Recent genetic findings in schizophrenia and their therapeutic relevance.
(2015)
PMID:25315827
cited
rare but penetrant large CNVs are associated with schizophrenia and account for ~10% of heritability.
confidence: 0.96
Several rare CNVs have genotypic relative risks in the 5–20 range
confidence: 0.90
Copy number variation: what is it and what has it told us about child psychiatric disorders?
(2013)
PMID:23880486
cited
An increased burden of rare CNVs ... observed ... in schizophrenia
confidence: 0.94
CNV studies have now established a significant role for rare (<1% in frequency) ... CNVs in risk for schizophrenia.
confidence: 0.96
A contribution of rare CNVs to disease is evident ... in patients as compared with controls ... schizophrenia.
confidence: 0.95
rare CNVs from large case-controls studies of SCZ ...
confidence: 0.90
possible involvement of rare copy number variations in schizophrenia ... has received substantial support
confidence: 0.94