Chrna4 associated_with nicotine

Subject: Chrna4
Relation: associated_with
Object: nicotine
p-value: —

Evidence from: primary | all sources

Evidence (5 sources)

Nominal association with CHRNA4 variants and nicotine dependence. (2013) PMID:23350800 cited

The two CHRNA4 SNPs implicated in this study with ND symptoms have been implicated previously in smoking related phenotypes.

confidence: 0.85

Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. (2012) PMID:22290489 cited

α4 subunit plays a role in the reinforcing effects of nicotine

confidence: 0.92

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (2010) PMID:20584212 cited

Evidence for association was observed ... for CHRNA4 ... in the development of nicotine dependence.

confidence: 0.95

Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. (2009) PMID:19654303 cited

CHRNA genes ... playing a role in development of nicotine dependence

confidence: 0.80

Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. (2008) PMID:18593715 cited

associations of SNPs in ... nAChR subunit genes with nicotine dependence

confidence: 0.80