rare variant associated_with phenotype

a set of rare variants appears to be collectively associated with a phenotype

one could perhaps test hierarchies of hypotheses about collections of variants and their biological impact on a phenotype

statistical analysis methods for relating rare variants to phenotypes of interest are needed

rare variants are likely to influence a trait

numerous rare variants may be detected ... but they may have disparate effects on phenotype

Determining which of the multitude of variants ... are responsible for a given phenotype ...