PPARα risk_factor_for hepatic steatosis

Pparαhep−/− mice showed marked increase in hepatic steatosis in response to 2 weeks of HFD feeding.

Both Pparαhep−/− and Pparα−/− mice showed spontaneous centrilobular steatosis.

selective PPARα deletion in hepatocytes (Pparαhep−/−) was sufficient to promote hepatic steatosis.

steatosis ... was further elevated in Pparα−/− mice