COMT regulates dopamine

Subject: COMT
Relation: regulates
Object: dopamine
p-value: —

Evidence from: primary | all sources

Evidence (5 sources)

Alcoholism and human electrophysiology. (2003) PMID:15303626 primary

COMT, the enzyme that metabolizes the brain chemicals (i.e., neurotransmitters) dopamine and norepinephrine (NE).

confidence: 0.95

Genetic studies of alcohol dependence in the context of the addiction cycle. (2017) PMID:28118990 cited

COMT ... modulates dopamine tone in the prefrontal cortex

confidence: 0.85

Cannabis controversies: how genetics can inform the study of comorbidity. (2014) PMID:24438181 cited

COMT codes for an enzyme that is instrumental in the degradation of endogenous amines, including dopamine

confidence: 0.95

Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls. (2011) PMID:21620981 cited

prominent contribution of COMT to DA regulation in the PFC

confidence: 0.96

Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls. (2011) PMID:21620981 cited

gene encoding the DA catabolizing enzyme catechol-o-methyltransferase

confidence: 0.95