NPY protective_against anxiety

Endogenous NPY reduces anxiety via actions in the amygdala

In the amygdala, NPY has anxiolytic effects that are mediated via activation of Y1 receptors.

NPY, being a potent, endogenous anxiolytic, is of interest in finding novel treatment targets for alcohol abuse.

targeting the NPY system ... may still offer an attractive strategy for developing novel ... anti-anxiety treatments

Intracerebroventricular infusion of NPY decreases the anxiety induced by ethanol withdrawal.