rs10482672 protective_against externalizing disorders
Evidence from:
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Evidence (4 sources)
Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African-American Adolescent Alcohol Abuse.
(2018)
PMID:27817096
cited
carrying a variant of NR3C1 (rs10482672) ... had the lowest risk for externalizing psychopathology.
confidence: 0.95
Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.
(2015)
PMID:26106668
cited
especially likely to benefit ... reduced likelihood of developing externalizing psychopathology if they did receive the Fast Track intervention.
confidence: 0.93
Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.
(2015)
PMID:26106668
cited
Fast Track intervention was more efficacious ... among carriers of the rs10482672 “A” allele (δ=−0.520, p=0.00006). 18% of treated carriers manifested externalizing vs 75% of controls.
confidence: 0.98
Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.
(2015)
PMID:26106668
cited
For “A” carriers, 18% of treated children manifested externalizing psychopathology ... compared to 75% of control children.
confidence: 0.96