HFD risk_factor_for hepatic steatosis

Subject: HFD
Relation: risk_factor_for
Object: hepatic steatosis
p-value: —

Evidence from: primary | all sources

Evidence (2 sources)

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. (2016) PMID:26838599 cited

Pparαhep−/− mice showed marked increase in hepatic steatosis in response to 2 weeks of HFD feeding.

confidence: 0.88

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. (2016) PMID:26838599 cited

short-term exposure to a high-fat diet ... mouse liver accumulated hepatic triglycerides and cholesterol esters. ... steatosis was twice higher in Pparαhep−/− mice

confidence: 0.96