externalizing disorders risk_factor_for substance use
Evidence from:
primary |
all sources
Evidence (10 sources)
Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics.
(2023)
PMID:37713023
primary
outcomes related to, or affected by, externalizing behaviors and disorders (e.g., ..., substance-use disorders, ...)
confidence: 0.85
Polygenic risk scores for alcohol involvement relate to brain structure in substance-naïve children: Results from the ABCD study.
(2021)
PMID:34092032
cited
externalizing problems ... believed to play an etiologic role in the development of substance use disorder
confidence: 0.90
the externalizing pathway may well be a dominant pathway of risk for SUDs
confidence: 0.90
various forms of externalizing symptoms all serve to increase risk for SUDs
confidence: 0.96
externalizing symptoms themselves may serve to moderate risk for substance involvement associated with the internalizing pathway
confidence: 0.70
externalizing symptoms may serve as a final common pathway to substance involvement, mediating the relation between childhood internalizing symptoms and substance use
confidence: 0.90
internalizing symptoms contribute little to the prediction of substance use in adolescence once risk associated with externalizing symptoms is considered
confidence: 0.90
Adolescent studies show a stronger effect of externalizing symptoms on substance use outcomes.
confidence: 0.92
Common genetic contributions to alcohol and cannabis use and dependence symptomatology.
(2010)
PMID:20028363
cited
adolescents with externalizing problems, who are at high risk for substance misuse
confidence: 0.90
Deviant P300 amplitude development in males is associated with paternal externalizing psychopathology.
(2008)
PMID:19025236
cited
externalizing dimension underlying vulnerability for substance use disorders
confidence: 0.95