rs1051730 risk_factor_for nicotine
Evidence from:
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Evidence (6 sources)
Genetic variability in the regulation of gene expression in ten regions of the human brain.
(2014)
PMID:25174004
cited
rs1051730 is a risk SNP for the interlinked phenotypes of lung cancer, smoking behavior and nicotine dependence
confidence: 0.98
Nicotinic acetylcholine receptor variation and response to smoking cessation therapies.
(2013)
PMID:23249876
cited
Smokers with reduced α5 subunit function and associated increased nicotine dependence might be expected...
confidence: 0.90
Nicotinic acetylcholine receptor variation and response to smoking cessation therapies.
(2013)
PMID:23249876
cited
rs1051730 significantly increases measures of nicotine dependence
confidence: 0.93
TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood.
(2011)
PMID:21168125
cited
The CHRNA3-rs1051730[A] has been associated with nicotine dependence.
confidence: 0.95
A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.
(2009)
PMID:19429911
cited
Women who continue to smoke in pregnancy are expected to have a higher frequency of the risk allele due to higher nicotine dependence.
confidence: 0.90
A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.
(2009)
PMID:19429911
cited
risk allele having two related effects, each reflecting a predisposition to nicotine dependence
confidence: 0.85