Ca2+ regulates BK channel

drive the BK channel Po toward the steady-state Po,ss in response to each [Ca2+] jump

The steady-state open probability (Po,ss) for a BK channel ... is a function of [Ca2+] and voltage.

calculated the BK Po as a function of the distance ... from the [Ca2+] spatial function

In response to a step function of [Ca2+] between 1 and 320 µM, BK channel currents develop with time constants between 40 and 5 ms at 0 mV.

[Ca2+] near the BK channels drops rapidly to the level below the EC50 when a Ca2+ spark terminates