rs16969968 risk_factor_for nicotine

rs16969968 ... as a risk factor for ... nicotine dependence

smokers at highest nicotine dependence risk being less likely to quit smoking overall

The Asn398 allele has been associated with nicotine dependence/heavy smoking.

association of rs16969968 to nicotine dependence is present

The asparagine allele at CHRNA5-rs16969968 has been associated with nicotine dependence/heavy smoking.

Individuals who have one copy of the risk variant have a 1.3‑fold increase in developing nicotine dependence; rs16969968 is in CHRNA5.

The variant CHRNA5 (D398N), which greatly increases the risk for nicotine dependence...

The association between rs16969968 and nicotine dependence has now been replicated in African-Americans.

genetic variant rs16969968 causes biological changes that alter the risk of developing nicotine dependence

rs16969968 ... is clearly implicated in risk for nicotine dependence ... in individuals of European descent

Our evidence for multiple common nicotine dependence risk alleles in the same gene region ... rs16969968 is ... a strong candidate to be a causal allele.

multiple SNP associations between CHRNA5-CHRNA3-CHRNB4 and nicotine dependence

These SNPs are responsible for two biological mechanisms affecting nicotine dependence risk: a coding change at CHRNA5 ... at rs16969968

The risk allele at rs16969968 ... association with nicotine dependence ...

rs16969968 represents a risk locus for nicotine dependence in African-Americans as well as in European-Americans.

This contrasts with the agreement between EA and AA association results for rs16969968.