Alcohol Use Disorder associated_with major depressive disorder

Subject: Alcohol Use Disorder
Relation: associated_with
Object: major depressive disorder
p-value: 2.19e-20

Evidence from: primary | all sources

Evidence (4 sources)

Integrated Single-Cell Multiomic Profiling of Caudate Nucleus Suggests Key Mechanisms in Alcohol Use Disorder. (2024) PMID:39149227 primary

AUD and major depression frequently co-occur

confidence: 0.80

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary

positive genetic correlations with ... MDD: rg = 0.406, p = 2.19 × 10−20

confidence: 0.98

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. (2023) PMID:38062264 cited

comorbidity of psychiatric disorders among these AUD cases is higher than expected ...

confidence: 0.85

Diagnosis and Pharmacotherapy of Alcohol Use Disorder: A Review. (2018) PMID:30167705 cited

AUD may be accompanied by co-occurring psychiatric disorders (e.g., ... major depressive ... disorders).

confidence: 0.96