APP-transgenic mice associated_with spatial learning
Evidence from:
primary |
all sources
Evidence (1 sources)
Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.
(2017)
PMID:27926491
cited
In APP-transgenic mice, specific spatial learning impairment is evident in young mice and becomes severe with age without the formation of plaques.
confidence: 0.90