polygenic risk score risk_factor_for substance use

Subject: polygenic risk score
Relation: risk_factor_for
Object: substance use
p-value: —

Evidence from: primary | all sources

Evidence (2 sources)

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses. (2023) PMID:37464041 cited

HRR increased with higher polygenic loads and was statistically significant for the 10th PRS decile... absolute risk for SUD reaching 21% in the 10th decile.

confidence: 0.94

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses. (2023) PMID:37464041 cited

Top PRS deciles showed increased absolute risk for substance use disorder (SUD).

confidence: 0.94