rs279858 risk_factor_for alcohol dependence
Evidence from:
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all sources
Evidence (5 sources)
GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures.
(2015)
PMID:26250693
cited
associations between the rs279858*C allele and increased risk for AD
confidence: 0.96
GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures.
(2015)
PMID:26250693
cited
rs279858 ... was the only candidate marker associated with AD
confidence: 0.94
AD-associated minor allele
confidence: 0.70
risk of AD in carriers of these minor alleles may, in part, be mediated by the decreased subjective negative responses to alcohol.
confidence: 0.85
decreased subjective response to alcohol of individuals carrying the minor allele G may ... mediate the increased risk for AD observed in population studies.
confidence: 0.90