ADH1B associated_with alcohol
Evidence from:
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Evidence (12 sources)
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
(2019)
PMID:30940813
primary
including three alcohol-metabolizing genes ... ADH1B ... associated with alcohol consumption
confidence: 0.96
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
(2019)
PMID:30940813
primary
Five of the loci were previously associated with a self-reported measure of alcohol consumption: GCKR, KLB, ADH1B, ADH1C, and SLC39A8.
confidence: 0.96
Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts.
(2019)
PMID:30336701
cited
identified numerous loci ... that influence alcohol consumption, including ADH1B/ADH1C/ADH5
confidence: 0.95
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).
(2017)
PMID:28937693
cited
a cluster of variants spanning the alcohol dehydrogenase genes (ADH1B, ADH1C, ADH5, ADH6, ADH7) ... linked to variation in alcohol consumption
confidence: 0.90
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).
(2017)
PMID:28937693
cited
identify eight independent loci associated with alcohol consumption... ADH1B is one of the four loci
confidence: 0.95
Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.
(2017)
PMID:28485404
cited
Second strongest association ... rs1229984, a missense SNP in ADH1B, which was associated with both alcohol consumption phenotypes.
confidence: 0.90
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).
(2017)
PMID:28937693
cited
several alcohol dehydrogenase genes (ADH1B, ADH1C, ADH5) that have all previously been implicated in alcohol consumption.
confidence: 0.96
Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.
(2017)
PMID:28485404
cited
effect on average alcohol drinking of ADH1B ...
confidence: 0.70
Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.
(2017)
PMID:28485404
cited
identified 4 loci associated with alcohol consumption ... including ADH1B
confidence: 0.96
The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks.
(2012)
PMID:22348705
cited
ADH1B ... influence alcohol consumption
confidence: 0.94
Polymorphisms in ADH1B influence alcohol consumption.
confidence: 0.90
Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes?
(2009)
PMID:19183129
cited
variation in these regions does affect alcohol consumption ... particularly on the ADH1B and GABRA2 genes
confidence: 0.95