OPRM1 associated_with adolescents

four tissues of the six tissues tested for OPRM1 favored the hypothesis that only a genetic association with OA at this locus is present

The mu-opioid receptor gene, OPRM1, has long been a target of OA research and drug development.

genetic loci associated with OA share a causal variant with the eQTLs for ... OPRM1

Gene level analyses ... showed significant associations with OPRM1 ... (p < 3.13 × 10–6).

Predicted genetically driven OPRM1 expression was significantly associated with OA in cerebellum.