OPRM1 A118G risk_factor_for alcohol dependence

The G allele was more frequent in AD women but not in AD men, indicating an association with Alcohol Dependence in the Korean cohort.

The association between A118G and alcohol dependence may be explained by different physiological responses to alcohol based on A118G genotype.

Another study found carriers of the G allele to be at increased risk for alcohol dependence in adult Caucasians.

A Meta-analysis of these Asian cohorts confirmed an effect of A118G genotype on susceptibility to alcohol dependence