major depressive disorder associated_with schizophrenia

mood and psychotic disorders (MDD, BIP, and SCZ)

We used MR to investigate the relationship between major depression and schizophrenia... bi-directional correlations... PGSMR=1.5×10−11

comparison of the major depression loci with 108 loci for schizophrenia identified six shared loci

our data strongly suggest the existence of biological processes common to major depression and schizophrenia

genetic associations for major depression (as with schizophrenia) tend to occur in genomic regions conserved across a range of placental mammals.

bidirectionally significant MR results are consistent a shared biological basis for major depression and schizophrenia