PPARA regulates Fgf21
Evidence from:
primary |
all sources
Evidence (3 sources)
CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model.
(2019)
PMID:29568101
primary
FGF21 is regulated by PPARα (ref. 25).
confidence: 0.95
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.
(2016)
PMID:26838599
cited
FGF21 ... were increased through a mechanism that is partly dependent on hepatic PPARα
confidence: 0.90
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.
(2016)
PMID:26838599
cited
Circulating FGF21 was strictly dependent on hepatocytic PPARα activation during fasting
confidence: 0.95