ADH1B associated_with alcohol dependence
Evidence from:
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Evidence (12 sources)
Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence.
(2024)
PMID:38405959
primary
identified three loci previously associated with alcohol dependence —ADH1B, ADH1C, and ADH4
confidence: 0.96
Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations.
(2021)
PMID:32652861
primary
different functional SNP in ADH1B ... have been linked to alcohol dependence
confidence: 0.80
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
(2019)
PMID:30940813
primary
the only GWS findings were two independent ADH1B variants ... in a meta-analysis of ... alcohol dependence
confidence: 0.96
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
(2019)
PMID:30940813
primary
the minor allele of which ... has been associated with alcohol dependence
confidence: 0.96
Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
(2019)
PMID:31090166
primary
variants within the alcohol metabolizing genes, notably ADH1B, ... are associated with AD
confidence: 0.90
Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort.
(2016)
PMID:25865819
primary
several known alcohol metabolism genes are located on chromosome 4q23 (ADH4, ADH5, ADH6, ADH1A, ADH1B, ADH1C)... to provide an estimate of polygenic risk for alcohol dependence
confidence: 0.80
KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex.
(2016)
PMID:26202629
primary
ADH1B and ALDH2 polymorphisms with alcohol dependence
confidence: 0.95
ADH1B variation ... most important genetic influence on ... dependence in EUR populations
confidence: 0.95
Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.
(2017)
PMID:28485404
cited
pharmacogenetic effect of missense variants in genes ... ADH1B ... influence ... risk of alcohol dependence.
confidence: 0.85
Genetic studies of alcohol dependence in the context of the addiction cycle.
(2017)
PMID:28118990
cited
Genome-wide significant (p < 10–8) and replicable SNPs were located in the following genes ... ADH1B ...
confidence: 0.96
Genetic studies of alcohol dependence in the context of the addiction cycle.
(2017)
PMID:28118990
cited
Genes involved with alcohol metabolism (alcohol dehydrogenase [ADH] ...) are also implicated
confidence: 0.94
Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses.
(2015)
PMID:26110981
cited
significant associations in alcohol metabolizing enzyme genes
confidence: 0.85