CHRNA5 interacts_with nicotine
Evidence from:
primary |
all sources
Evidence (5 sources)
their protein products interact directly with nicotine
confidence: 0.96
Genetic and environmental contributions to the relationships between brain structure and average lifetime cigarette use.
(2015)
PMID:25690561
cited
Genes ... (CHRNA5, CHRNA3 and CHRNB4) alter receptor activity and sensitivity to nicotine
confidence: 0.90
Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes.
(2012)
PMID:22290489
cited
involvement of the α5 ... subunits ... in response to nicotine
confidence: 0.92
Habenular α5 nicotinic receptor subunit signalling controls nicotine intake.
(2011)
PMID:21278726
cited
α5* nAChRs (encoded by CHRNA5) may differentially regulate activation ... in response to nicotine
confidence: 0.85
Habenular α5 nicotinic receptor subunit signalling controls nicotine intake.
(2011)
PMID:21278726
cited
deficient α5* nAChR signaling appears to attenuate the negative effects of nicotine
confidence: 0.80