ADH1B associated_with AUDIT-C

Subject: ADH1B
Relation: associated_with
Object: AUDIT-C
p-value: —

Evidence from: primary | all sources

Evidence (5 sources)

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary

including the two most commonly identified alcohol metabolism genes (ADH1B and ADH1C) ... associated with AUDIT-C score

confidence: 0.95

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary

rs1229984 in ADH1B shows increased significance for AUDIT-C after BMI correction

confidence: 0.88

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary

found a stronger association between age-adjusted mean AUDIT-C score and ADH1B minor allele frequency

confidence: 0.93

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary

Meta-analysis ... yielded 13 independent loci, 5 of which were previously associated with a self-reported measure of alcohol consumption: GCKR, KLB, ADH1B, ADH1C, and SLC39A8.

confidence: 0.96

Genetics of substance use disorders in the era of big data. (2021) PMID:34211176 cited

ADH1B was again the lead locus (for both traits)

confidence: 0.96