iPSCs associated_with Alzheimer's disease
Evidence from:
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Evidence (3 sources)
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
(2018)
PMID:29632371
cited
induced pluripotent stem cells (iPSCs) ... are promising in vitro models for studying disease pathogenesis ...
confidence: 0.95
Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.
(2017)
PMID:27926491
cited
Generation of induced pluripotent stem cells (iPSCs) ... presents an attractive and promising approach to model early stages of AD in vitro
confidence: 0.90
Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes.
(2016)
PMID:27622770
cited
iPSC-derived neural cells to model various aspects of AD pathology
confidence: 0.88