OPRM1 A118G risk_factor_for Alcohol Use Disorder

the G allele confers genetic vulnerability to alcohol dependence

Extensive work has explored the relationship between OPRM1 A118G and ... alcohol abuse disorders.

One variant associated with AUDs is ... rs1799971 ...

G minor allele carriers may bestow a genetic susceptibility toward AUDs.

G allele carriers of Asian ancestry were at increased risk for developing an AUD.

Adolescents with the A/G or G/G genotypes at A118G are three times more likely to have an alcohol use disorder than those with the A/A genotype.

Adolescents who met criteria for an AUD diagnosis had a higher prevalence of the G allele (51.9%) than non-AUD youth (16.3%).

risk associated with the A118G SNP of the OPRM1 gene ... would experience greater risk for developing an AUD

adolescent carriers of the G allele who reported high levels of deviant peer affiliation were more likely to develop an AUD

association between ... the A118G SNP, and risk for developing an AUD during adolescence.