apoE4 regulates APP

Subject: apoE4
Relation: regulates
Object: APP
p-value: —

Evidence from: primary | all sources

Evidence (2 sources)

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. (2018) PMID:29632371 cited

apoE4 significantly stimulates Aβ production ... likely by enhancing APP processing

confidence: 0.92

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. (2018) PMID:29632371 cited

apoE4 enhances APP expression, leading to increased Aβ production

confidence: 0.95