OPRM1 A118G interacts_with beta-endorphin

rs1799971 ... to be more potent in beta-endorphin binding.

Initially described as a gain-of-function mutation due to increased affinity for β-End.

rs1799971 ... was shown to be more potent in beta-endorphin binding and receptor activity

an increased affinity for endogenous opioids, particularly beta-endorphin