CHRNA5 protective_against drug dependence

Subject: CHRNA5
Relation: protective_against
Object: drug dependence
p-value: —

Evidence from: primary | all sources

Evidence (1 sources)

Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior. (2012) PMID:23040810 cited

Decreasing the expression ... results in increased nicotine self-administration, suggesting that this cholinergic system normally acts as a brake on drug reward

confidence: 0.85