Kcnj6 regulates Kcnj6
Evidence from:
primary |
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Evidence (6 sources)
Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons.
(2023)
PMID:36207584
primary
KCNJ6 encodes the G protein-gated inwardly rectifying potassium channel subunit 2 (GIRK2)
confidence: 0.96
Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons.
(2023)
PMID:36207584
primary
silencing KCNJ6 ... eliminated GIRK2 immunoreactivity
confidence: 0.95
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
Kcnj6 gene dose regulated the levels of Kir3.2 (F1,9 = 3.3, p = 0.005)
confidence: 0.95
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
increase in Kir3.2 levels approximated the increase in Kcnj6 dosage in Ts65Dn:Kcnj6+++ vs. 2N:Kcnj6++ mice
confidence: 0.85
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
levels of Kir3.2 were reduced proportional to gene dose (p = 0.0003) in Kcnj6+− vs. Kcnj6++ mice
confidence: 0.96
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
Genetically normalizing Kcnj6 gene dose reduced to 2N levels the Kir3.2 protein subunit
confidence: 0.95