rare variant risk_factor_for schizophrenia
Evidence from:
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all sources
Evidence (8 sources)
Common biological networks underlie genetic risk for alcoholism in African- and European-American populations.
(2013)
PMID:23607416
primary
rare variants could not alone account for R2 signals generated from genome-wide, polymarker scoring of psychiatric disorders such as schizophrenia
confidence: 0.70
Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
(2022)
PMID:35396580
cited
rare coding variants (RCVs) ... are genetic ... variation in risk ... associated with schizophrenia
confidence: 0.95
What Should a Psychiatrist Know About Genetics? Review and Recommendations From the Residency Education Committee of the International Society of Psychiatric Genetics.
(2018)
PMID:30549495
cited
up to 3%−5% of cases of ... schizophrenia
confidence: 0.95
Recent genetic findings in schizophrenia and their therapeutic relevance.
(2015)
PMID:25315827
cited
more ... rare variants ... will no doubt be found ... contributing to the genetic risk of schizophrenia
confidence: 0.90
Recent genetic findings in schizophrenia and their therapeutic relevance.
(2015)
PMID:25315827
cited
discovery that rare variants also contribute to the genetic predisposition
confidence: 0.94
Recent genetic findings in schizophrenia and their therapeutic relevance.
(2015)
PMID:25315827
cited
excess of such variants in schizophrenia
confidence: 0.85
For schizophrenia ... multiple risk rare variants with moderate to large effect sizes have been already reported
confidence: 0.95
Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.
(2009)
PMID:19065143
cited
Recent papers describing an enrichment of copy number variants in schizophrenia ... have raised the possibility of a significant contribution from rare events.
confidence: 0.95