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ADH1B risk_factor_for alcohol dependence

Subject
ADH1B
Relation
risk_factor_for
Object
alcohol dependence
p-value
—
Evidence from: primary | all sources

Evidence (15 sources)

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary
Three previously associated with alcohol dependence—ADH1B, ADH1C, and ADH4.
confidence: 0.97
Ethanol activates immune response in lymphoblastoid cells. (2019) PMID:30639126 primary
The largest meta-analysis ... found only one gene associated with the disorder at genome-wide significance, ADH1B.
confidence: 0.96
Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans. (2015) PMID:26036284 primary
All four SNPs in ADH1B were previously shown to be significantly associated with AD.
confidence: 0.90
Genetics of substance use disorders in the era of big data. (2021) PMID:34211176 cited
effect was mostly due to the contribution of the ... ADH1B loci
confidence: 0.95
Genetics of substance use disorders in the era of big data. (2021) PMID:34211176 cited
the alcohol metabolism genes ... ADH1B ... in the predisposition to alcohol use, abuse, and dependence
confidence: 0.95
Genetic studies of alcohol dependence in the context of the addiction cycle. (2017) PMID:28118990 cited
genetic variation in the alcohol metabolizing genes ... risk for alcohol dependence.
confidence: 0.90
Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses. (2015) PMID:26110981 cited
the ADH gene cluster appears to have the greatest effect on AD risk
confidence: 0.90
Dissecting ancestry genomic background in substance dependence genome-wide association studies. (2015) PMID:26267224 cited
differences observed between AAs and EAs in AD GWAS outcomes of ADH1B
confidence: 0.80
Genome-wide association discoveries of alcohol dependence. (2014) PMID:25278008 cited
genes in the ethanol metabolic pathway (e.g., ADH1B ...) are candidates for alcohol dependence
confidence: 0.95
The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks. (2012) PMID:22348705 cited
implicated as risk factors for developing alcohol abuse or dependence
confidence: 0.93
The genetics of alcohol dependence: advancing towards systems-based approaches. (2012) PMID:22854292 cited
variants within the genes encoding the hepatic forms, ADH1B ... have been related to alcohol dependence.
confidence: 0.93
An Interdisciplinary Approach to Studying Gene-Environment Interactions: From Twin Studies to Gene Identification and Back. (2011) PMID:34385894 cited
robust association with polymorphisms in genes encoding alcohol metabolizing enzymes: ... alcohol dehydrogenase (ADH)...
confidence: 0.80
Genome wide association for addiction: replicated results and comparisons of two analytic approaches. (2010) PMID:20098672 cited
acetaldehyde dehydrogenase/alcohol dehydrogenase variants to risk for alcohol dependence in Asians
confidence: 0.94
Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes? (2009) PMID:19183129 cited
variation in these regions does affect ... dependence risk ... particularly on the ADH1B and GABRA2 genes
confidence: 0.95
Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10. (2009) PMID:18930185 cited
specific risk allele ... involves ADH loci and risk for alcohol dependence.
confidence: 0.90