Alcohol Use Disorder associated_with prefrontal cortex
Evidence from:
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Evidence (6 sources)
Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder.
(2025)
PMID:41083468
primary
snRNA-seq study of nuclei from the prefrontal cortex ... found differences in expression associated with AUD
confidence: 0.94
Integrated Single-Cell Multiomic Profiling of Caudate Nucleus Suggests Key Mechanisms in Alcohol Use Disorder.
(2024)
PMID:39149227
primary
Bulk RNA‑seq uncovered differentially expressed genes in the prefrontal cortex of rats and humans.
confidence: 0.95
Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.
(2021)
PMID:32333417
cited
individuals with AUD have long‑lasting alterations in brain chemistry and lower brain volume and cortical thickness (e.g., ... prefrontal cortex [PFC] ...) compared to healthy controls
confidence: 0.95
Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.
(2021)
PMID:32333417
cited
common areas susceptible to the neurotoxic effects of alcohol are apparent, including cortico-limbic regions like the prefrontal cortex
confidence: 0.90
Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.
(2021)
PMID:32333417
cited
The pattern of brain volume loss was reversed from that demonstrated in the PFC.
confidence: 0.70
Age-varying associations between substance use behaviors and depressive symptoms during adolescence and young adulthood.
(2015)
PMID:26483358
cited
youth with an alcohol use disorder show structural deficits in the ... prefrontal cortex compared to youth without an alcohol use disorder.
confidence: 0.95