polygenic risk score risk_factor_for type 2 diabetes

OR increased to approximately 4.50 when using top 2% of the PRS to identify high-risk individuals (batch 1: OR = 4.62, P value = 7.47E−31).

Individuals in the top 2% of the PRS distribution had significantly increased T2D risk

When using the trans-ancestry PRS as a predictor of T2D status... OR comparing individuals in the top 2% of the PRS distribution with the rest... 1.98 (95% CI: 1.43–2.74; P value = 4.34E−05)

The trans-ancestry PRS explained 9.2% of the variation in T2D status and individuals in the top decile of the PRS had increased risk of T2D.

top 2% of a trans-ancestry PRS distribution can identify individuals ... with a roughly 2.5–4.5-fold increase in T2D risk

Hispanic individuals with high PRS had a substantially increased risk of T2D, with an OR of 6.87 (95% CI: 3.11–15.15; P value = 1.81E−06).