de novo variant risk_factor_for bipolar disorder

Frequencies of de novo CNVs were significantly higher (4.3%) in bipolar disorder as compared with healthy individuals (0.09%).

overall contribution of de novo CNVs ... to disease risk could be substantial ... for BD and SCZ.

strong evidence implicating rare de novo CNVs in genetic risk for bipolar disorder

Rare de novo copy-number mutations are significantly enriched in bipolar disorder and in schizophrenia.