CRF targets CRF1R

CRF actions involve presynaptic CRF1R activation at the CeA GABAergic synapses.

CRF ... enhance GABAergic transmission through activation of CRF1 receptors.

CRF binds to both receptors, but has greater affinity for the CRF1R.

CRF is critical to the stress response through its activation of the corticotropin-releasing hormone type I receptor (CRHR1)

CRF ... act differentially at CRF1 ... receptors

CRF and urocortin CRF enhance postsynaptic responses to GABA through activation of the CRF1R

CRF is largely a CRF1R agonist and displays 18-fold greater affinity for CRF1R than CRF2R

effects opposite those mediated by CRF through actions at CRF1 receptors