Kcnj6 risk_factor_for cognition
Evidence from:
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Evidence (5 sources)
Genetic studies of alcohol dependence in the context of the addiction cycle.
(2017)
PMID:28118990
cited
potassium/GIRK channels ... mediating cognitive deficits in alcohol dependence
confidence: 0.80
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
reduce the effect of increased Kir3.2 expression may offer a means to moderate cognitive deficits in DS
confidence: 0.85
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
Increased expression of Kcnj6 is necessary for the significant cognitive impairment in this model of DS.
confidence: 0.96
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
Kcnj6 is a candidate for contributing through increased dose to cognitive deficits.
confidence: 0.95
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
(2017)
PMID:28342823
cited
increased expression of Kir3.2 ... resulting in cognitive impairment
confidence: 0.90