rs4654327 interacts_with naltrexone

significant OPRD1^4 × medication interaction (β = −0.99, SE = 0.222, t = −4.46, p < .0001)

models producing significant genotype × medication interactions were followed up by a simple effects analysis

A-allele carriers showed greater naltrexone‑induced blunting of alcohol craving as compared to G‑allele homozygotes