ALDH2 regulates acetaldehyde
Evidence from:
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Evidence (6 sources)
ALDH2 ... encodes aldehyde dehydrogenase, an enzyme responsible for metabolizing acetaldehyde ...
confidence: 0.96
Peroxisome proliferator-activated receptor and retinoic x receptor in alcoholic liver disease.
(2009)
PMID:19756185
cited
altered ADL/ADLH activities ... may account for that damage
confidence: 0.75
The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants.
(2007)
PMID:17718394
cited
The severe effects of the ALDH2*2 variant on acetaldehyde levels and alcoholism risk demonstrate that...
confidence: 0.90
The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants.
(2007)
PMID:17718394
cited
the mitochondrial ALDH2 enzyme ... is the most important enzyme for eliminating acetaldehyde from the body
confidence: 0.93
The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants.
(2007)
PMID:17718394
cited
They probably decrease alcoholism risk by increasing local acetaldehyde levels, either because ... acetaldehyde is oxidized more slowly.
confidence: 0.90
The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants.
(2007)
PMID:17718394
cited
the inactive ALDH2*2 allele ... no longer oxidizes acetaldehyde to acetate
confidence: 0.93