PKC regulates GABAA receptor

reduced PKC-dependent GABAA receptor phosphorylation increases receptor binding to the AP-2 and promotes receptor endocytosis

PKC ... phosphorylation of GABAA receptors decreases receptor activation

Reduced PKC-dependent GABAA receptor phosphorylation enhances receptor binding to the AP-2 and promotes their endocytosis

Several protein kinases, including PKC ... can phosphorylate these subunits

effects of these protein kinases on other ion channels interfere with therapeutic strategies for modulation of GABAA receptors.