AUDIT-C associated_with auditory

Subject: AUDIT-C
Relation: associated_with
Object: auditory
p-value: 1.85e-14

Evidence from: primary | all sources

Evidence (8 sources)

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary

SNP-based heritability (h2 SNP) was estimated ... for both AUDIT-C and AUD

confidence: 0.80

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary

most SNPs have the same direction of effect for AUDIT-C and AUD, consistent with the high genetic correlation between the traits

confidence: 0.95

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary

multiple apparently independent signals for both AUDIT-C and AUD

confidence: 0.80

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary

moderate-to-high genetic correlation between the traits: 0.522 in EAs and 0.930 in AAs

confidence: 0.95

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary

both AUDIT-C and AUD PRS were associated with AUDIT-C and AUD phenotypes

confidence: 0.90

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary

We estimated the genetic correlation (rg) between AUDIT-C and AUD (from MVP).

confidence: 0.96

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary

significant genetic overlap between the AUDIT-C and AUD diagnosis

confidence: 0.95

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. (2019) PMID:30940813 primary

The rg between AUDIT-C and AUD was 0.930 (s.e. = 0.122, p = 1.85 × 10−14) in AAs

confidence: 0.98