rare variant associated_with missing heritability

suggest a more central role for rare variants ... in pathogenesis

explanations presented to explain the missing heritability, some of which include: undetected rare variants of large effect

rare variants might account for at least some of the missing heritability

Much of the speculation about missing heritability ... has focused on the possible contribution of variants of low minor allele frequency (MAF)...

Low frequency variants of intermediate effect might also contribute to explaining missing heritability