OPRM1 A118G protective_against relapse

Subject: OPRM1 A118G
Relation: protective_against
Object: relapse
p-value: —

Evidence from: primary | all sources

Evidence (4 sources)

Review: Pharmacogenetics of alcoholism treatment: Implications of ethnic diversity. (2017) PMID:28134463 cited

A/G and G/G carriers had lower rates of relapse ... compared to A/A carriers, suggesting this polymorphism can identify individuals more likely to benefit from NTX.

confidence: 0.94

Pharmacogenetics of OPRM1. (2014) PMID:24201053 cited

A recent meta-analysis concluded that individuals with the G/G or A/G genotypes did have reduced relapse rates compared to A/A individuals

confidence: 0.92

Pharmacogenetics of OPRM1. (2014) PMID:24201053 cited

G allele had reduced relapse rates when treated with naltrexone.

confidence: 0.90

Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol. (2012) PMID:22954510 cited

G-allele carriers have lower relapse rates in clinical trials of naltrexone for alcoholism.

confidence: 0.94